Every GLP-1, compared
Average weight-loss figures are trial averages over roughly 16–18 months; individual results vary widely. Diabetes brands are used off-label for weight loss.
| Drug | Molecule | Form | Approved for | Avg weight loss | Maker |
|---|---|---|---|---|---|
| Wegovy | Semaglutide (GLP-1) | Weekly injection | Weight management; CV risk | ~15% | Novo Nordisk |
| Zepbound | Tirzepatide (GIP/GLP-1) | Weekly injection | Weight management; sleep apnea | ~20% | Eli Lilly |
| Ozempic | Semaglutide (GLP-1) | Weekly injection | Type 2 diabetes; CV risk | (off-label) | Novo Nordisk |
| Mounjaro | Tirzepatide (GIP/GLP-1) | Weekly injection | Type 2 diabetes | (off-label) | Eli Lilly |
| Saxenda | Liraglutide (GLP-1) | Daily injection | Weight management | ~5–8% | Novo Nordisk |
| Rybelsus | Semaglutide (GLP-1) | Daily pill | Type 2 diabetes | (off-label) | Novo Nordisk |
See the full GLP-1 medications guide for every approved brand and how they relate. Figures are general and change — always confirm against current FDA labeling.
Direct comparisons
The match-ups people search most, answered with a table and a clear "which is right for you."
Ozempic vs Wegovy
Same drug, different job — dose, approval, weight loss and cost.
Compare → Weight lossZepbound vs Wegovy
Tirzepatide vs semaglutide — which wins on average weight loss.
Compare → DiabetesMounjaro vs Ozempic
The dual-agonist vs the classic GLP-1, head to head.
Compare → MoleculeSemaglutide vs Tirzepatide
Single vs dual agonist, and the brands each is sold under.
Compare → Weight lossBest GLP-1 for weight loss
An honest ranking — and why "best" isn't just the biggest number.
Read → Big pictureGLP-1s vs bariatric surgery
Medication or surgery? Results, durability, cost and who each suits.
Read →